Cellular response to indole-3-methanol

Across TCGA patient cohorts, RNA activity of the Cellular response to indole-3-methanol pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST4, POF1B, and BNIPL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to indole-3-methanol activity versus MAST4 in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAST4 →	+0.615	+1.161	.002	<.001	3	4
LSCC	POF1B →	+1.550	+0.516	<.001	.006	3	4
HNSC	BNIPL →	+1.334	+1.048	<.001	<.001	3	4
LSCC	KIAA1671 →	+0.492	+0.285	.003	.003	3	4
HNSC	TTC22 →	+0.787	+0.992	<.001	.001	3	4
UCEC	NIPAL2 →	+0.568	+0.970	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071681 vs MAST4 — UCEC

Explore this scatter interactively →