Response to indole-3-methanol

Across TCGA cell cohorts, RNA activity of the Response to indole-3-methanol pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRD5A1, STXBP5, and APOL6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRD5A1 grouped by Response to indole-3-methanol-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SRD5A1 →	-0.728	-0.652	.008	.002	3	5
BREAST	STXBP5 →	-0.940	-0.997	.002	.003	3	5
LUNG_NSCLC_LUAD	APOL6 →	-1.298	-0.940	.002	.002	3	5
SOFT_TISSUE	PIGT →	-1.317	-0.441	.001	.002	3	5
SOFT_TISSUE	SOGA1 →	-1.020	-0.331	.004	.007	2	6
KIDNEY	MAP3K2 →	-0.845	-1.191	.007	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRD5A1 by Response to indole-3-methanol activity — BREAST

Explore this box plot interactively →