Response to indole-3-methanol

Across TCGA cell cohorts, RNA activity of the Response to indole-3-methanol pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH1, MARVELD3, and CDH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to indole-3-methanol activity versus CDH1 in URINARY_TRACT (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDH1 →	+5.232	+0.496	<.001	<.001	3	10
LUNG_NSCLC_LUSC	MARVELD3 →	+3.718	+0.602	<.001	.005	3	8
URINARY_TRACT	CDH3 →	+5.822	+0.559	.001	.001	3	7
URINARY_TRACT	GRHL2 →	+3.901	+0.463	<.001	<.001	3	7
URINARY_TRACT	FXYD3 →	+6.336	+0.486	.006	<.001	3	7
PANCREAS	KLC3 →	+1.874	+0.478	.003	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071680 vs CDH1 — URINARY_TRACT

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