Commissural neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Commissural neuron axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO1, HDAC2, and WDR43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Commissural neuron axon guidance activity versus XPO1 in HNSC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	XPO1 →	+0.162	+0.064	.003	.002	3	6
HNSC	HDAC2 →	+0.262	+0.058	<.001	<.001	3	5
LUAD	WDR43 →	+0.234	+0.048	.001	.002	3	5
LUAD	ZC3HC1 →	+0.132	+0.046	<.001	<.001	3	5
HNSC	CAD →	+0.267	+0.066	.001	.006	3	5
HNSC	MSH2 →	+0.292	+0.049	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071679 vs XPO1 — HNSC

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