Commissural neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Commissural neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCLK2, HM13, and EEF1AKMT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Commissural neuron axon guidance activity versus DCLK2 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCLK2 →	+0.440	+0.420	.009	.004	3	4
LUAD	HM13 →	-0.236	-0.538	.004	.006	3	3
CCRCC	EEF1AKMT3 →	+0.652	+0.535	<.001	.005	3	3
LSCC	SHROOM3 →	+0.491	+0.649	.003	<.001	3	3
LSCC	PXDC1 →	+0.550	+0.633	.001	.006	3	3
LSCC	RNU11-6P →	+0.912	+0.681	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071679 vs DCLK2 — BRCA

Explore this scatter interactively →