Commissural neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Commissural neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM17, NRP1, and TMEM39A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Commissural neuron axon guidance activity versus ADAM17 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ADAM17 →	+0.932	+0.161	<.001	<.001	3	10
SKIN	NRP1 →	+2.872	+0.123	<.001	<.001	3	9
SKIN	TMEM39A →	+0.639	+0.129	.001	.002	3	9
URINARY_TRACT	ECE1 →	+0.948	+0.123	.007	.001	3	8
OVARY	ZNF333 →	+0.691	+0.118	.001	<.001	3	7
BREAST	TMEM39B →	+1.090	+0.177	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071679 vs ADAM17 — BREAST

Explore this scatter interactively →