Commissural neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Commissural neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAM1, TANGO6, and RANGRF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Commissural neuron axon guidance activity versus NCAM1 in SOFT_TISSUE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NCAM1 →	+5.642	+1.925	<.001	<.001	3	5
BONE	TANGO6 →	-0.673	-2.219	.005	.004	3	3
LUNG_NSCLC_LUSC	RANGRF →	-2.173	-1.804	.008	<.001	2	4
LARGE_INTESTINE	CDKN2D →	+1.004	+1.004	.006	.005	3	3
LUNG_NSCLC_LUAD	RPL37 →	-0.713	-0.695	.001	.007	3	3
LUNG_NSCLC_LUAD	GABARAP →	-0.621	-0.638	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071679 vs NCAM1 — SOFT_TISSUE

Explore this scatter interactively →