Positive regulation of mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, PALD1, and RPS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mononuclear cell migration activity versus CD47 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD47 →	+2.027	+0.270	<.001	.003	3	8
BLOOD_Lymphoma	PALD1 →	-2.300	-0.208	<.001	<.001	3	6
BREAST	RPS3 →	-0.894	-0.232	.001	.001	3	5
BONE	AP2B1 →	+1.284	+0.315	.001	.002	3	5
LUNG_NSCLC_LUAD	COMT →	+1.080	+0.255	.002	<.001	3	5
BLOOD_Leukemia	RPP40 →	-0.579	-0.135	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071677 vs CD47 — BONE

Explore this scatter interactively →