Regulation of mononuclear cell migration

Across TCGA patient cohorts, RNA activity of the Regulation of mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, CCRL2, and CD300LB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mononuclear cell migration activity versus TMEM97 in LSCC (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM97 →	-0.903	-0.166	<.001	<.001	3	7
OV	CCRL2 →	+0.790	+0.356	<.001	<.001	3	7
OV	CD300LB →	+0.429	+0.212	<.001	<.001	3	7
OV	CSF2RA →	+0.680	+0.220	<.001	<.001	3	7
LSCC	PIK3CG →	+0.853	+0.224	<.001	<.001	3	7
OV	LILRB2 →	+1.095	+0.362	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071675 vs TMEM97 — LSCC

Explore this scatter interactively →