Regulation of mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3D, SELENOW, and INPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mononuclear cell migration activity versus RAB3D in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAB3D →	+1.432	+0.191	.002	<.001	3	6
LUNG_SCLC	SELENOW →	+1.620	+0.217	.001	.005	3	6
STOMACH	INPP1 →	+2.262	+0.221	<.001	<.001	3	5
LIVER	TSTD3 →	-0.566	-0.202	.008	.006	3	5
BREAST	ATP5F1C →	-0.679	-0.203	.001	<.001	3	5
BLOOD_Lymphoma	PALD1 →	-2.292	-0.161	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071675 vs RAB3D — BLOOD_Leukemia

Explore this scatter interactively →