Mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGGT2, ASNS, and SMIM13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UGGT2 grouped by Mononuclear cell migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UGGT2 →	-2.087	-0.733	<.001	.001	3	3
BLOOD_Leukemia	ASNS →	-1.921	-0.857	.004	.006	3	3
LUNG_NSCLC_LUAD	SMIM13 →	+0.417	+0.288	.007	.008	3	3
BLOOD_Myeloma	LGALS8 →	-1.371	-1.247	.002	.001	3	2
BLOOD_Myeloma	RIPK1 →	-0.655	-1.437	.004	.002	2	3
BLOOD_Myeloma	RAG1 →	+1.250	+1.829	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UGGT2 by Mononuclear cell migration activity — BLOOD_Leukemia

Explore this box plot interactively →