Mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAM1, TNFRSF12A, and STX4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mononuclear cell migration activity versus DRAM1 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DRAM1 →	+2.403	+0.380	<.001	<.001	3	7
BLOOD_Lymphoma	TNFRSF12A →	+2.003	+0.301	<.001	.001	3	7
BLOOD_Lymphoma	STX4 →	+1.195	+0.390	<.001	<.001	3	6
BLOOD_Lymphoma	RAB27A →	+2.756	+0.488	<.001	<.001	3	6
BLOOD_Lymphoma	STING1 →	+6.018	+0.464	<.001	<.001	3	6
LIVER	ITGB3 →	+3.202	+0.322	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071674 vs DRAM1 — BLOOD_Lymphoma

Explore this scatter interactively →