Mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Mononuclear cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO1C, ANXA1, and CAPNS1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mononuclear cell migration activity versus CORO1C in URINARY_TRACT (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CORO1C →	+1.594	+0.264	.001	.008	2	12
LUNG_SCLC	ANXA1 →	+4.269	+0.464	<.001	<.001	3	11
OVARY	CAPNS1 →	+1.789	+0.412	<.001	<.001	3	10
BREAST	MSN →	+1.369	+0.224	.002	.001	3	10
PANCREAS	ACTN4 →	+1.415	+0.313	.002	<.001	3	9
LUNG_SCLC	LGALS1 →	+4.776	+0.406	.004	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071674 vs CORO1C — URINARY_TRACT

Explore this scatter interactively →