Regulation of smooth muscle cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of smooth muscle cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR141, C3AR1, and PIK3CG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smooth muscle cell chemotaxis activity versus GPR141 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPR141 →	+0.703	+0.181	<.001	<.001	3	6
COAD	C3AR1 →	+0.684	+0.164	.001	<.001	3	5
COAD	PIK3CG →	+0.449	+0.135	.004	.009	2	6
COAD	MS4A6A →	+0.811	+0.194	<.001	<.001	3	5
CCRCC	GAPT →	+0.681	+0.115	<.001	.002	3	5
CCRCC	CSF2RA →	+0.576	+0.104	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071671 vs GPR141 — BRCA

Explore this scatter interactively →