Regulation of smooth muscle cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of smooth muscle cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG2A, SPOPL, and SAFB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG2A grouped by Regulation of smooth muscle cell chemotaxis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATG2A →	+0.581	+0.822	<.001	.001	3	4
BREAST	SPOPL →	+0.626	+0.892	.003	<.001	3	4
BLOOD_Leukemia	SAFB2 →	+0.471	+1.257	.002	<.001	3	4
LUNG_SCLC	PARP1 →	-0.783	-1.306	.006	.005	3	3
LUNG_SCLC	ENAH →	-0.920	-1.162	.003	.002	3	3
LUNG_SCLC	MOB2 →	+0.548	+1.083	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG2A by Regulation of smooth muscle cell chemotaxis activity — BREAST

Explore this box plot interactively →