Positive regulation of chemokine (C-C motif) ligand 5 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, CD52, and IL10RA, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine (C-C motif) ligand 5 production activity versus CYTH4 in LAML (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CYTH4 →	-1.222	-0.091	<.001	<.001	3	22
SCLC	CD52 →	-2.272	-0.259	<.001	<.001	3	22
CHOL	IL10RA →	-1.454	-0.140	<.001	<.001	3	21
SCLC	GZMK →	-2.364	-0.242	<.001	<.001	3	21
SCLC	SLAMF1 →	-1.647	-0.198	<.001	.005	3	21
SCLC	CD48 →	-2.323	-0.241	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071651 vs CYTH4 — LAML

Explore this scatter interactively →