Positive regulation of chemokine (C-C motif) ligand 5 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, ASPN, and SERPING1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine (C-C motif) ligand 5 production activity versus RCN3 in CCRCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RCN3 →	-0.468	-0.091	<.001	<.001	3	6
COAD	ASPN →	-0.751	-0.084	.002	.001	3	6
CCRCC	SERPING1 →	-0.480	-0.087	<.001	<.001	3	6
CCRCC	FLNC →	-0.887	-0.094	.001	.001	3	6
OV	ITGA7 →	-0.532	-0.077	.001	<.001	3	6
GBM	ABI3BP →	-0.862	-0.108	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071651 vs RCN3 — CCRCC

Explore this scatter interactively →