Positive regulation of chemokine (C-C motif) ligand 5 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALHM2, C1QL3, and ITM2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine (C-C motif) ligand 5 production activity versus CALHM2 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CALHM2 →	-0.418	-0.637	.006	.004	3	4
GBM	C1QL3 →	-0.936	-0.711	.005	.002	3	4
LSCC	ITM2B →	+0.510	+0.671	<.001	<.001	3	3
LSCC	H1-10-AS1 →	-0.460	-0.520	.001	.008	3	3
CCRCC	CDC42EP3 →	-0.520	-0.624	.001	.007	3	3
CCRCC	SLC35D1 →	+0.497	+0.729	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071651 vs CALHM2 — CCRCC

Explore this scatter interactively →