Negative regulation of transforming growth factor beta production

Across TCGA patient cohorts, RNA activity of the Negative regulation of transforming growth factor beta production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1298, MFAP2, and COL1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta production activity versus MAP1B_S1298 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1B_S1298 →	+0.700	+0.069	<.001	.002	3	6
UCEC	MFAP2 →	+0.546	+0.096	.003	.002	3	5
GBM	COL1A1 →	+0.892	+0.076	<.001	<.001	3	5
CCRCC	MAP1B_S1427 →	+0.468	+0.027	.007	.009	3	5
GBM	EPS8 →	+0.269	+0.089	<.001	<.001	3	5
GBM	CD109 →	+0.622	+0.067	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071635 vs MAP1B_S1298 — UCEC

Explore this scatter interactively →