Positive regulation of granulocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, CEACAM3, and SDR39U1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of granulocyte chemotaxis activity versus BCL2A1 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCL2A1 →	+0.958	+0.131	<.001	<.001	3	6
PDAC	CEACAM3 →	+0.685	+0.118	<.001	.008	3	6
GBM	SDR39U1 →	-0.411	-0.157	<.001	<.001	3	6
GBM	PKN2 →	-0.332	-0.138	<.001	<.001	3	6
GBM	DOK3 →	+0.665	+0.154	.001	<.001	3	5
GBM	CD300A →	+0.961	+0.160	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071624 vs BCL2A1 — GBM

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