Positive regulation of granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBASH3B, NUAK2, and LPCAT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of granulocyte chemotaxis activity versus UBASH3B in SOFT_TISSUE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UBASH3B →	+3.725	+0.492	.001	.004	3	5
OVARY	NUAK2 →	+2.541	+0.327	.001	.001	2	6
LUNG_NSCLC_LUSC	LPCAT2 →	+1.755	+0.222	.006	.005	3	5
STOMACH	IGDCC4 →	-2.203	-0.366	.002	.008	3	4
STOMACH	DNMT3A →	-2.774	-0.326	.001	.005	3	4
STOMACH	CALD1 →	-3.570	-0.280	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071624 vs UBASH3B — SOFT_TISSUE

Explore this scatter interactively →