Negative regulation of granulocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of granulocyte chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A1AP_S82, CCNK_S329, and DPP4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of granulocyte chemotaxis activity versus SLC4A1AP_S82 in UCEC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC4A1AP_S82 →	-1.167	-0.267	<.001	<.001	3	10
OV	CCNK_S329 →	-1.772	-0.125	<.001	<.001	3	9
COAD	DPP4 →	+1.246	+0.108	<.001	<.001	3	9
UCEC	SRSF11_S449 →	-1.561	-0.259	<.001	<.001	3	8
LSCC	WRNIP1_S65 →	-1.217	-0.109	<.001	<.001	3	8
OV	ZNF638_S552 →	-1.406	-0.115	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071623 vs SLC4A1AP_S82 — UCEC

Explore this scatter interactively →