Negative regulation of granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP17, ASTN2, and PTK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP17 grouped by Negative regulation of granulocyte chemotaxis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARHGAP17 →	-2.043	-1.657	.004	<.001	3	4
OESOPHAGUS	ASTN2 →	-1.250	-1.247	.003	<.001	3	4
OESOPHAGUS	PTK2 →	-1.023	-1.021	.004	.004	3	4
KIDNEY	MRPL20 →	+0.771	+1.021	<.001	.001	3	4
BREAST	PIAS3 →	-0.656	-0.745	.006	<.001	3	4
OVARY	ITFG1 →	-0.719	-1.131	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP17 by Negative regulation of granulocyte chemotaxis activity — BLOOD_Lymphoma

Explore this box plot interactively →