Regulation of granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF2, NCOA2, and APPL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF2 grouped by Regulation of granulocyte chemotaxis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TAF2 →	-0.590	-0.707	.004	.007	3	4
SOFT_TISSUE	NCOA2 →	-1.079	-0.253	.004	.003	2	4
LARGE_INTESTINE	APPL1 →	-0.693	-0.199	.008	.003	3	3
KIDNEY	SLMAP →	-0.752	-0.742	<.001	.004	3	3
URINARY_TRACT	MAZ →	-1.297	-0.342	.009	.006	3	3
PANCREAS	QTRT2 →	-0.694	-0.315	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF2 by Regulation of granulocyte chemotaxis activity — KIDNEY

Explore this box plot interactively →