Granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASTKD3, CDC42EP2, and ZBTB45, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FASTKD3 grouped by Granulocyte chemotaxis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FASTKD3 →	-0.871	-0.956	<.001	.003	3	5
OESOPHAGUS	CDC42EP2 →	+1.081	+1.191	.005	.005	3	4
LARGE_INTESTINE	ZBTB45 →	+0.692	+0.973	.002	.007	3	3
LARGE_INTESTINE	STRADB →	-0.770	-1.190	.005	<.001	3	3
STOMACH	CLDN12 →	+1.016	+1.207	<.001	<.001	3	3
STOMACH	MYO1A →	+2.977	+1.284	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FASTKD3 by Granulocyte chemotaxis activity — LUNG_SCLC

Explore this box plot interactively →