Granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, ZNF581, and FAH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte chemotaxis activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+4.506	+0.265	<.001	<.001	3	7
BLOOD_Lymphoma	ZNF581 →	-1.301	-0.265	<.001	.001	3	6
BLOOD_Lymphoma	FAH →	+1.192	+0.237	<.001	.001	3	6
BLOOD_Leukemia	RILPL2 →	+1.715	+0.239	<.001	.001	3	5
SOFT_TISSUE	JRKL →	+1.247	+0.416	.002	<.001	3	5
BLOOD_Leukemia	S100A6 →	+3.164	+0.314	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071621 vs ANXA1 — SOFT_TISSUE

Explore this scatter interactively →