Granulocyte colony-stimulating factor production

pathway activity — cross-omics
GO:0071611Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Granulocyte colony-stimulating factor production pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP6, GGTA1, and SEC24AP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADGIMAP6 →+0.537+0.539.001.00835
COADGGTA1 →+0.676+0.296.006.00235
BRCASEC24AP1 →+0.371+0.632.005.00234
CCRCCGIMAP8 →+0.580+0.627<.001<.00134
CCRCCZNF366 →+0.634+0.560<.001.00134
LSCCTRIM38 →+0.392+0.437<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration