Macrophage inflammatory protein-1 alpha production

pathway activity — cross-omics
GO:0071608Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Macrophage inflammatory protein-1 alpha production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM2, C8orf31, and RN7SKP72, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCCMTM2 →+0.482+0.377.001.00533
LUADC8orf31 →-0.559-0.347.002.00533
LUADRN7SKP72 →+0.518+0.346.004.00133
LUADMTCYBP23 →+0.330+0.304.001.00733
LSCCFCGR3B →+1.190+0.372.001.00433
PDACRPS2P7 →-0.698-0.352<.001.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration