Transforming growth factor beta production

Across TCGA cell cohorts, RNA activity of the Transforming growth factor beta production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN1B, PMP22, and FUT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCN1B grouped by Transforming growth factor beta production-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCN1B →	+1.087	+0.664	.008	.003	2	5
CNS	PMP22 →	+2.187	+0.577	.007	.008	3	4
LUNG_NSCLC_LUAD	FUT3 →	-2.308	-0.593	<.001	.009	3	4
BREAST	TBXA2R →	+0.509	+0.609	.004	.006	3	3
BLOOD_Lymphoma	GOT1 →	-1.104	-1.555	.005	.009	2	4
BLOOD_Lymphoma	PMVK →	+0.549	+1.589	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCN1B by Transforming growth factor beta production activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →