Otic vesicle morphogenesis

Across TCGA patient cohorts, RNA activity of the Otic vesicle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, PROX1-AS1, and RRM2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otic vesicle morphogenesis activity versus PROX1 in UCEC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PROX1 →	+1.884	+0.761	<.001	.001	3	5
COAD	PROX1-AS1 →	+0.433	+0.590	<.001	.008	3	5
LUAD	RRM2B →	-0.491	-0.714	.001	.002	3	4
LSCC	SOX9 →	+1.369	+0.702	<.001	<.001	2	5
COAD	KIAA0513 →	-0.445	-0.541	.005	.003	3	4
UCEC	RCN2 →	+0.528	+0.520	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071600 vs PROX1 — UCEC

Explore this scatter interactively →