Otic vesicle morphogenesis

Across TCGA cell cohorts, RNA activity of the Otic vesicle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMTK2, SLC45A4, and RPLP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMTK2 grouped by Otic vesicle morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LMTK2 →	+0.694	+1.354	.004	.002	3	4
BLOOD_Myeloma	SLC45A4 →	+1.196	+1.680	<.001	<.001	3	4
LUNG_SCLC	RPLP1 →	-0.828	-1.475	<.001	.002	3	3
OESOPHAGUS	CYRIB →	+0.954	+1.430	.009	.002	3	3
BLOOD_Leukemia	SLC25A13 →	+1.157	+0.999	.001	.001	3	3
KIDNEY	HELB →	+0.402	+1.132	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMTK2 by Otic vesicle morphogenesis activity — LIVER

Explore this box plot interactively →