Otic vesicle development

Across TCGA patient cohorts, RNA activity of the Otic vesicle development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSN, SOX9, and ZNF326, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otic vesicle development activity versus MSN in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSN →	-0.539	-0.073	<.001	.001	3	6
LSCC	SOX9 →	+0.839	+0.070	.001	.001	3	5
LSCC	ZNF326 →	+0.332	+0.062	.002	.003	3	5
BRCA	ACTR2 →	-0.222	-0.049	.001	<.001	3	5
OV	MADD_S930 →	+0.531	+0.036	.005	.008	3	5
BRCA	MYD88 →	-0.195	-0.035	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071599 vs MSN — GBM

Explore this scatter interactively →