Otic vesicle development

Across TCGA cell cohorts, RNA activity of the Otic vesicle development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS1, RFC5, and DCLRE1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PUS1 grouped by Otic vesicle development-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PUS1 →	-0.591	-0.776	.002	.003	3	5
BLOOD_Myeloma	RFC5 →	-0.875	-1.279	.002	.005	3	4
BLOOD_Lymphoma	DCLRE1A →	-1.020	-1.653	.004	<.001	2	5
KIDNEY	ZFP2 →	-0.589	-0.435	.002	<.001	3	3
KIDNEY	CEBPZOS →	+0.626	+0.337	.002	.005	3	3
STOMACH	SH3TC2 →	+1.987	+1.071	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PUS1 by Otic vesicle development activity — CNS

Explore this box plot interactively →