Otic vesicle development

Across TCGA cell cohorts, RNA activity of the Otic vesicle development pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are MN-64, Camptothecin, and SN-38, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MN-64 grouped by Otic vesicle development-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MN-64 →	-0.346	-0.269	.006	.032	3	2
LUNG_SCLC	Camptothecin →	-1.506	-0.456	.012	.019	3	1
LUNG_SCLC	SN-38 →	-1.733	-0.456	.006	.019	3	1
LUNG_SCLC	BIBR-1532 →	-0.799	-0.456	.003	.019	3	1
LARGE_INTESTINE	Navitoclax →	+0.866	+0.485	.022	.037	3	1
LARGE_INTESTINE	(5Z)-7-Oxozeaenol →	-0.516	-0.485	.018	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MN-64 by Otic vesicle development activity — OVARY

Explore this box plot interactively →