Lymphocyte aggregation

Across TCGA patient cohorts, RNA activity of the Lymphocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK10, RAC2, and MYO1F, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte aggregation activity versus STK10 in KICH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	STK10 →	+1.049	+0.072	<.001	<.001	3	32
ACC	RAC2 →	+2.115	+0.078	<.001	<.001	3	30
CHOL	MYO1F →	+1.778	+0.113	<.001	.002	3	29
DLBC	CD28 →	+2.011	+0.105	<.001	<.001	3	29
CHOL	CSF1R →	+1.823	+0.092	<.001	.002	3	29
SCLC	SPN →	+2.224	+0.219	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071593 vs STK10 — KICH

Explore this scatter interactively →