Lymphocyte aggregation

Across TCGA patient cohorts, RNA activity of the Lymphocyte aggregation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte aggregation activity versus RCSD1 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCSD1 →	+0.658	+0.123	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.808	+0.114	<.001	<.001	3	10
BRCA	SASH3 →	+0.635	+0.074	<.001	<.001	3	10
GBM	SKAP2 →	+0.633	+0.101	<.001	<.001	3	10
LSCC	STK10 →	+0.475	+0.124	<.001	<.001	3	10
OV	STK4 →	+0.369	+0.057	.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071593 vs RCSD1 — UCEC

Explore this scatter interactively →