Lymphocyte aggregation

Across TCGA cell cohorts, RNA activity of the Lymphocyte aggregation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX4, MARK3, and CHP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX4 grouped by Lymphocyte aggregation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOX4 →	+2.268	+1.348	.001	<.001	3	5
LUNG_NSCLC_LUAD	MARK3 →	-0.559	-1.148	<.001	<.001	3	5
CNS	CHP1 →	-0.478	-0.897	.007	.001	3	4
CNS	MEX3A →	+1.429	+0.938	<.001	.001	3	4
CNS	OAT →	-0.842	-0.963	.007	<.001	3	4
SKIN	KLF9 →	+0.942	+0.899	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX4 by Lymphocyte aggregation activity — BLOOD_Leukemia

Explore this box plot interactively →