Lymphocyte aggregation

Across TCGA cell cohorts, RNA activity of the Lymphocyte aggregation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA9, HM13, and CDK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CA9 grouped by Lymphocyte aggregation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CA9 →	+0.206	+0.215	.006	<.001	3	4
BLOOD_Leukemia	HM13 →	-0.125	-0.131	.003	<.001	3	4
BREAST	CDK4 →	-0.540	-0.772	.001	.005	3	4
OESOPHAGUS	COQ3 →	-0.141	-0.167	.002	.001	3	3
LUNG_NSCLC_LUAD	DNAAF4-CCPG1 →	+0.138	+0.563	.007	.003	3	3
BLOOD_Leukemia	NOP16 →	-0.266	-0.140	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CA9 by Lymphocyte aggregation activity — BONE

Explore this box plot interactively →