Zinc ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Zinc ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPA1, PPIF, and CTSZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion import across plasma membrane activity versus RPA1 in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPA1 →	-0.264	-0.084	<.001	<.001	3	5
OV	PPIF →	+0.485	+0.058	.001	.003	3	5
GBM	CTSZ →	+0.631	+0.135	<.001	<.001	3	5
GBM	ETFDH →	+0.348	+0.082	<.001	<.001	3	5
LSCC	LSM4 →	-0.185	-0.088	<.001	<.001	3	5
GBM	NUP43 →	-0.185	-0.080	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071578 vs RPA1 — GBM

Explore this scatter interactively →