Zinc ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Zinc ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC30A1, SLC39A14, and SEC62_T158, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion import across plasma membrane activity versus SLC30A1 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC30A1 →	+0.452	+0.570	<.001	<.001	3	4
CCRCC	SLC39A14 →	+0.683	+0.793	<.001	<.001	3	4
BRCA	SEC62_T158 →	+0.927	+0.608	<.001	<.001	3	4
BRCA	CANX_S564 →	+1.382	+0.792	<.001	<.001	3	4
UCEC	MLEC →	+0.981	+1.086	<.001	<.001	3	4
UCEC	RAB1A →	+0.509	+1.021	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071578 vs SLC30A1 — BRCA

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