Response to dexamethasone

Across TCGA patient cohorts, RNA activity of the Response to dexamethasone pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN2, DAB2_S723, and FAP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dexamethasone activity versus CNN2 in OV (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNN2 →	+0.546	+0.028	<.001	<.001	3	9
GBM	DAB2_S723 →	+0.892	+0.058	<.001	<.001	3	9
OV	FAP →	+0.952	+0.029	<.001	<.001	3	9
BRCA	FLNA →	+0.562	+0.051	<.001	<.001	3	9
OV	PDLIM3 →	+0.645	+0.031	<.001	<.001	3	9
OV	PRKG1 →	+0.565	+0.034	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071548 vs CNN2 — OV

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