Response to dexamethasone

Across TCGA patient cohorts, RNA activity of the Response to dexamethasone pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF17, PDGFD, and RPL21P91, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dexamethasone activity versus DCAF17 in CCRCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DCAF17 →	-0.212	-0.091	.007	.004	3	3
LSCC	PDGFD →	-0.645	-0.128	.009	.009	3	3
PDAC	RPL21P91 →	+0.065	+0.150	.004	.009	3	3
CCRCC	FERMT1 →	+0.682	+0.069	<.001	.002	3	2
CCRCC	STK33 →	+0.803	+0.092	.007	.001	3	2
CCRCC	MINDY1 →	+0.337	+0.070	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071548 vs DCAF17 — CCRCC

Explore this scatter interactively →