Response to dexamethasone

Across TCGA cell cohorts, RNA activity of the Response to dexamethasone pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF678, BTG2, and METRN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF678 grouped by Response to dexamethasone-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF678 →	+1.685	+0.287	.001	.004	3	4
SKIN	BTG2 →	+1.687	+0.596	<.001	.002	3	4
BLOOD_Myeloma	METRN →	-2.040	-0.218	.008	.006	3	3
BLOOD_Myeloma	ZFAND5 →	+1.347	+0.354	<.001	.001	3	3
BLOOD_Myeloma	PIK3CD →	-1.593	-0.256	.001	.002	3	3
KIDNEY	ZC3H11A →	+0.565	+0.317	.003	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF678 by Response to dexamethasone activity — BONE

Explore this box plot interactively →