Response to dexamethasone

Across TCGA cell cohorts, RNA activity of the Response to dexamethasone pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA1A, PFDN1, and N4BP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPA1A grouped by Response to dexamethasone-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HSPA1A →	+0.211	+0.104	.006	.004	3	5
STOMACH	PFDN1 →	-0.233	-0.099	<.001	.001	3	4
BREAST	N4BP2 →	+0.291	+0.111	.001	.005	3	4
OVARY	ZNF12 →	+0.226	+0.082	.002	.003	3	4
OVARY	BCL3 →	+0.187	+0.108	<.001	.001	3	4
BREAST	ECM2 →	-0.157	-0.095	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPA1A by Response to dexamethasone activity — BONE

Explore this box plot interactively →