Diphosphoinositol polyphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Diphosphoinositol polyphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCF20_S1372, UNG, and BCLAF3_S402, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diphosphoinositol polyphosphate metabolic process activity versus TCF20_S1372 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TCF20_S1372 →	+0.564	+0.105	<.001	<.001	3	5
COAD	UNG →	+0.403	+0.106	<.001	<.001	3	5
LSCC	BCLAF3_S402 →	+0.668	+0.113	<.001	<.001	3	5
LSCC	BIN2 →	-0.267	-0.069	.003	.004	3	5
COAD	GPSM3 →	-0.422	-0.075	<.001	.001	3	5
BRCA	GYG1 →	-0.265	-0.087	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071543 vs TCF20_S1372 — LSCC

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