Diphosphoinositol polyphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Diphosphoinositol polyphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC4A, ERLNC1, and LINC02343, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diphosphoinositol polyphosphate metabolic process activity versus CLEC4A in LSCC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC4A →	-0.399	-0.173	<.001	.004	3	3
BRCA	ERLNC1 →	+0.671	+0.192	<.001	<.001	3	3
BRCA	LINC02343 →	+1.212	+0.146	.003	.002	3	3
LSCC	PARP4 →	-0.595	-0.191	.003	<.001	3	2
LSCC	NFIC →	-0.775	-0.203	.001	.002	3	2
LSCC	BTNL9 →	+1.243	+0.243	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071543 vs CLEC4A — LSCC

Explore this scatter interactively →