Diphosphoinositol polyphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Diphosphoinositol polyphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COMMD4, LGALS1, and EFCAB11, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diphosphoinositol polyphosphate metabolic process activity versus COMMD4 in BLOOD_Leukemia (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COMMD4 →	-0.519	-0.239	.005	.003	3	2
BLOOD_Leukemia	LGALS1 →	+2.967	+0.277	.001	.001	3	1
BLOOD_Leukemia	EFCAB11 →	-0.819	-0.357	.006	.007	3	1
BLOOD_Leukemia	FANCD2 →	-1.290	-0.323	.009	.002	3	1
BLOOD_Leukemia	CETN3 →	-0.859	-0.265	.004	.002	3	1
BLOOD_Leukemia	EMSY →	-0.757	-0.357	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071543 vs COMMD4 — BLOOD_Leukemia

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