Genomic imprinting

Across TCGA patient cohorts, RNA activity of the Genomic imprinting pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT3A, MSI1, and TTC39B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genomic imprinting activity versus DNMT3A in LSCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNMT3A →	+0.646	+0.863	<.001	<.001	3	4
LSCC	MSI1 →	+1.019	+0.676	<.001	.004	3	4
LUAD	TTC39B →	-0.481	-0.786	.001	.001	3	4
GBM	UBE2V1P13 →	+1.089	+0.952	<.001	<.001	3	4
GBM	MIR22HG →	-0.542	-0.845	.004	<.001	3	4
LUAD	GINS1 →	+0.812	+0.565	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071514 vs DNMT3A — LSCC

Explore this scatter interactively →