Genomic imprinting

Across TCGA cell cohorts, RNA activity of the Genomic imprinting pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1B, SAMD9L, and IGFBP6, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genomic imprinting activity versus KDM1B in STOMACH (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KDM1B →	+1.420	+0.253	<.001	<.001	3	18
LUNG_NSCLC_LUSC	SAMD9L →	-2.512	-0.231	.001	<.001	3	8
BREAST	IGFBP6 →	-2.491	-0.141	.001	<.001	3	7
BONE	HAUS7 →	+0.763	+0.139	.004	.004	3	7
LARGE_INTESTINE	ZDBF2 →	-0.825	-0.137	<.001	<.001	3	7
LUNG_NSCLC_LUSC	CARD6 →	-1.924	-0.215	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071514 vs KDM1B — STOMACH

Explore this scatter interactively →