Genomic imprinting

Across TCGA cell cohorts, RNA activity of the Genomic imprinting pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALAS1, PYGM, and RBBP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Genomic imprinting activity versus ALAS1 in OESOPHAGUS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ALAS1 →	-1.182	-0.749	<.001	.006	3	5
LARGE_INTESTINE	PYGM →	+0.381	+1.176	<.001	.002	3	5
BLOOD_Leukemia	RBBP4 →	+0.799	+0.786	<.001	.003	3	4
OESOPHAGUS	YEATS2 →	+1.309	+1.307	.005	.006	3	4
LUNG_SCLC	SFXN3 →	-2.112	-1.195	<.001	.002	3	4
BLOOD_Leukemia	STEAP3 →	-2.299	-0.989	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071514 vs ALAS1 — OESOPHAGUS

Explore this scatter interactively →